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Free Radical Therapy Blog » genes

Posts Tagged ‘genes’

Gene Testing – Great Promise for the Future, but Too Early to Replace FRT Chemistry

Wednesday, October 13th, 2010

Someone asked me, “I’ve heard about DNA testing where a drop of blood is put into some sort of machine and treatment is determined from the reading. Could this be a path to healing?”

Genetic profiling, the test that’s referred to here, holds great promise for the future. Yet at the current level of understanding it can also grossly mislead – away from evaluating the homeostatic controls, protein status, and toxic footprints of chemistry.

DNA is known to code for specific proteins, which is good, and thus would seem a good way to know if you have the capability to produce the proteins (or not) that associate with health and disease. Yet, only 2% of our DNA codes for protein. The remaining DNA, as revealed in the profile, still contains the same four letter codes, but serves only as a switching and signaling mechanism – the details of which are largely still a mystery. What is not a mystery is the healthful influence that diet, lifestyle, and the environment are able to exert on the support of gene expression and suppression.

In those situations where we may carry an unhealthy gene, then the effort we make toward tailoring the dietary and lifestyle plans can awaken a compensating gene. So until the doctor doing the genetic testing can assure you that he or she understands the switching and signaling genes per the genetic profile, perhaps you are better off avoiding the test. Currently, you are better off performing a health model-based chemistry and tailoring your patients’ health programs from that perspective.

Alzheimer’s Risk and the APOE gene…there IS something you can do.

Saturday, April 5th, 2008

The thinking of doctors, researchers, and patients alike is so tightly wired to the disease model concept of health that they can’t see the true value of genetic testing. They are mired in the belief that the outcome should always be a new drug tailored to fit the needs of your genetic makeup. Ho hum. Such thinking is at times a real bore.

For the latest “poor us, nothing can be done” attitude I refer you to the February 22, 2008 issue of Science (319), where they announce the forthcoming availability of APOE genetic testing. The reality, is that KNOWING YOUR APO E genotype can result in a better outcome than depression and anxiety. It gives you an appropriate strategy for altering your diet and lifestyle to reduce your risk, while providing great benefit towards better health.

A few years ago I contributed a chapter in a book on Egg Nutrition, edited by Ron Watson, Ph.D., and published by Iowa State University Press. The chapter title was something like “Whole Eggs: The Magic Bullet”. A second version was published in our own Health Realities Journal. In both of those instances references were given of foods that could upregulate or downregulate the expression of this gene.

Depending upon your phenotype, the four key purposes of Apo E are:

(1) To redistribute cholesterol in the body from areas of high concentration to where it is most needed;

(2) to provide a means of transporting mercury and other heavy metals out of the body (via. cysteine residues);

(3) to provide the arginine residue necessary for the synthesis of nitric oxide (NO) to bring about control of smooth muscle and to kill bacteria; and

(4) to repair nerve myelin.

Eggs and butter are known to be most effective in upregulating the gene, while no eggs and butter may be the best way to downregulate its expression. People with Apo E 4/4 should certainly be given this information. Dr. Robert Mahley of the Gladstone Foundation in San Francisco was first to report this, references for which are in the publications mentioned. So, while it is the person with the Apo E 4/4 who must be most careful about avoiding eggs and butter, most people benefit from eggs and butter. These people who express Apo E 2/3, and Apo E 2/2, can not only eat eggs and butter as often as they’d like, but could also expect to control the onset and progression of arterial disease by doing so (as long as they have followed the standard rules for eating eggs). For people who have the Apo E 2/2 reading they should know that the excess arginine leaves them at higher risk for Type II diabetes and the metabolic syndrome, which should give them incentives to really work on this. For people who find they have the Apo E 4/4, Apo E 4/3, or Apl E 4/2 phenotype they are likely to benefit greatly from following FRT and improving glutathione status in the process.

Remember, free radicals that lead to Alzheimer’s are most likely to occur when you are acid. Addressing this is most important for the person with Apo E 4/4, as they will have an abundance of the nitric oxide-producing arginine. So when a bump occurs on the head and inflammation results in the making of excess nitric oxide in the brain you can see how the excess acid from this event could result in the enormous amount of free radicals from mercury (for instance) in causing the initial damage. OK, so you can keep on listening to the poor souls who cannot see beyond the disease model, who are afraid that the testing will cause people to go commit suicide or develop deep depression, or you can get with it and realize that THE HUMAN BODY IS DESIGNED TO WIN, NOT TO LOSE. Knowing allows you to develop a winning strategy. Incidentally, my forthcoming book on FRT will carry that very title, Designed To Win.