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Free Radical Therapy Blog » acid stress

Posts Tagged ‘acid stress’

Stem Cell Therapy, Cancer and FRT: The Good, the Bad and the Promising (Part Two)

Wednesday, February 16th, 2011

Stem cell harvest

Stem cell harvest

Now for the Promising…

I’m going to start today with a personal twist on stem cell research. More than 10 years ago, the Institute for Health Realities sponsored a super symposium on cancer in Colorado Springs. At the meeting, our featured speaker, Mary Hendricks, Ph.D.*, showed that cancer may use a stem cell to metastasize, becoming most aggressive as it develops its own blood supply (rather than depending upon any existing supply route). Cancer accomplished this feat by mimicking our process of angiogenesis, but with its own unique architecture. With such being the case, it is clear that the new blood supply was no accident. It was all part of cancer’s ongoing strategy.**

Dr. Hendricks then gave us hope of finding an answer to the disease. Cancer, she explained, doesn’t start with a stem cell. It must be acquired later, from us. Cancer begins its life attached to endothelium using a glue-like protein, E-cadherin. It is during this initial stage of attachment that our own body is best equipped to kill it through programmed cell death (apoptosis). If we fail to kill it during its early stage, a time when our body is likely to be suffering the negative impact of the six subclinical defects characteristic of FRT, we run the risk of inadvertently activating a set of enzymes, called the MMPs, that loosen E-cadherin’s grip on the cancer. Upon being set free, the cancer starts to express a set of genetic instructions of its own, some of which work toward recruiting a stem cell from among our own adult stem cells.

The same six subclinical events that allow for the inadvertent activation of MMP enzymes, particularly acid stress and an anaerobic tendency, have long been known to associate with cancer onset. Dr. Otto Warburg won the Nobel Prize for this revelation back in the 1930’s. These imbalances, as was later discovered, impart to the cancer the ability to recruit one of our stem cells for its benefit. It is these key events that give emphasis to the importance of prevention by applying the Designed2Win Model of Health. Stopping cancer early has long been preferred over later, as once it separates from the endothelium the person affected is at greater disadvantage, which then calls for medical intervention.

In the coming weeks and months much discussion will appear in the news relative to how science is planning to counter the possibility of transplanting cancer during stem cell therapy. Someone will find a way to lessen the risk. Yet, the key point to take away from this, is that clinicians should get very serious with their patients with the concept of prevention. Free Radical Therapy may be the best approach to this end, as it deals with the six subclinical events important for maintaining the integrity of E-cadherin long enough for our immune system to kill the cancer early on. Similarly, there is some evidence that addressing the six cellular subclinical homeostatic controls assessed through chemistry may likewise protect T cell function while helping to derail cancer’s ability to recruit our adult stem cell for its own benefit.

“Prevention has its own rewards, that you may never know the disease you are trying to prevent.” ~ Author unknown


* Dr. Mary Hendricks was president of FASEB at the time of the seminar. FASEB is the largest life science organization in the world, with 70,000 member scientists. Her discovery that cancer undergoes angiogenesis mimicry provided an important answer to why anti-angiogenesis drugs often fail, and what you might do to correct the problem.

** The complete recording from this symposium is available from our office. Ask for the Super Symposium 2000 series, or order here.

Managing Eosinophilia

Thursday, September 30th, 2010

How Delivering Free Radical Therapy According to the Designed2Win Health Model Provided a Positive Outcome

Every now and then a FRT health provider may run into a client who presents a confusing situation that hadn’t been solved with meds, and really can’t get solved through FRT without returning to its health model basis. An example is a recent client who demonstrated an eosinophilic white blood count of more than 20%. Less than 4% is normal, so 20% is not healthy, especially when allowed to remain that high, as the amount of toxins released by eosinophils aimed at killing parasites but which can be stimulated by any allergen are certain to damage healthy tissues. Such a scenario affecting the lungs can cause severe compromise in lung function, leading to COPD, asthma or a tumor.

In this scenario the culprit is generally some allergen that has stimulated both the mast cells and the basophilic white blood cells to release histamine. The histamine helps stimulate bone marrow to produce more eosinophils, and the cycle continues until something is done to either blunt the effect of histamine or blunt the flood of histamine-like molecules that anti-histamine meds generally fail to touch. So, what do you do?

Addressing the role of acid stress is always the place to begin, since acidity is certain to amplify the release of histamine due to the mast cell and basophilic response to the allergen. Acidity follows the presence and action of any toxin, including that of a parasite. Thus a more alkaline environment tends to require fewer histamine-like particles. The eosinophil count falls accordingly.

How else you might go about reducing the amount of histamine – and thereby the eosinophil count – can be deduced by reviewing the key source of histamine. It is made from the amino acid histidine. Knowing this you might be tempted to restrict foods that are rich sources of histidine. The problem with this strategy is that histidine also provides the imidazole ring that is so important in buffering the acids all over the body. So, any restriction of the key amino acid can be self-defeating.

The Designed2Win attitude is needed to solve this problem. During exercise, the body releases the amino acid alanine, which serves to stimulate the making of HDL cholesterol while also serving as the substrate for the synthesis of carnosine. Carnosine is used to sponge away the lactic acid produced during exercise, thereby slowing fatigue. Too, the more alanine present at any given moment, the more the body will be prompted to use histidine for the making of carnosine at the expense of making histamine.

Based on this reality, the following suggestion was made to the health provider who was caring for the person in question: Follow the acid/base balancing maneuver with one that diverts histidine away from the making of histamine and towards the making of carnosine. By administering 3 grams L-alanine (not beta alanine) twice daily for a week (for a 150 lb person), followed by once daily for two weeks, the clinician noted a drop in the total eosinophil count from 20% to 6% within 3 weeks. This became far more manageable and less threatening to the person’s health.

Now, of course, you wouldn’t recommend this protocol to everyone you see. Histidine has a life beyond the making of either carnosine or histamine. So easing up on the high supplementation at some point will be essential in order to comply with the body’s winning design.