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Free Radical Therapy Blog » Designed2Win

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Stem Cell Therapy, Cancer and FRT: The Good, the Bad and the Promising (Part Two)

Wednesday, February 16th, 2011

Stem cell harvest

Stem cell harvest

Now for the Promising…

I’m going to start today with a personal twist on stem cell research. More than 10 years ago, the Institute for Health Realities sponsored a super symposium on cancer in Colorado Springs. At the meeting, our featured speaker, Mary Hendricks, Ph.D.*, showed that cancer may use a stem cell to metastasize, becoming most aggressive as it develops its own blood supply (rather than depending upon any existing supply route). Cancer accomplished this feat by mimicking our process of angiogenesis, but with its own unique architecture. With such being the case, it is clear that the new blood supply was no accident. It was all part of cancer’s ongoing strategy.**

Dr. Hendricks then gave us hope of finding an answer to the disease. Cancer, she explained, doesn’t start with a stem cell. It must be acquired later, from us. Cancer begins its life attached to endothelium using a glue-like protein, E-cadherin. It is during this initial stage of attachment that our own body is best equipped to kill it through programmed cell death (apoptosis). If we fail to kill it during its early stage, a time when our body is likely to be suffering the negative impact of the six subclinical defects characteristic of FRT, we run the risk of inadvertently activating a set of enzymes, called the MMPs, that loosen E-cadherin’s grip on the cancer. Upon being set free, the cancer starts to express a set of genetic instructions of its own, some of which work toward recruiting a stem cell from among our own adult stem cells.

The same six subclinical events that allow for the inadvertent activation of MMP enzymes, particularly acid stress and an anaerobic tendency, have long been known to associate with cancer onset. Dr. Otto Warburg won the Nobel Prize for this revelation back in the 1930’s. These imbalances, as was later discovered, impart to the cancer the ability to recruit one of our stem cells for its benefit. It is these key events that give emphasis to the importance of prevention by applying the Designed2Win Model of Health. Stopping cancer early has long been preferred over later, as once it separates from the endothelium the person affected is at greater disadvantage, which then calls for medical intervention.

In the coming weeks and months much discussion will appear in the news relative to how science is planning to counter the possibility of transplanting cancer during stem cell therapy. Someone will find a way to lessen the risk. Yet, the key point to take away from this, is that clinicians should get very serious with their patients with the concept of prevention. Free Radical Therapy may be the best approach to this end, as it deals with the six subclinical events important for maintaining the integrity of E-cadherin long enough for our immune system to kill the cancer early on. Similarly, there is some evidence that addressing the six cellular subclinical homeostatic controls assessed through chemistry may likewise protect T cell function while helping to derail cancer’s ability to recruit our adult stem cell for its own benefit.

“Prevention has its own rewards, that you may never know the disease you are trying to prevent.” ~ Author unknown

* Dr. Mary Hendricks was president of FASEB at the time of the seminar. FASEB is the largest life science organization in the world, with 70,000 member scientists. Her discovery that cancer undergoes angiogenesis mimicry provided an important answer to why anti-angiogenesis drugs often fail, and what you might do to correct the problem.

** The complete recording from this symposium is available from our office. Ask for the Super Symposium 2000 series, or order here.

Fun with National Chemistry Week – A New Perspective on Ancient Beer

Wednesday, October 27th, 2010

As a member of the American Chemical Society, I thought a fun way to observe National Chemistry Week would be to review the work of Jyllian Kemsley [C&, pg 48 Oct 18, 2010] on the health benefit of early beer.

The antibiotic tetracycline has long been observed in the bone of Egyptian mummies. At first it was thought to be a contaminant, but closer examination showed that the finding held true for the mummified remains of children and adults alike.

The mystery began to clear with the findings of an anthropology team from Emory University [Armelagos, G., Am J Phys Anthropol 143: 151, 2010], when the same was found within the bones of ancient Nubians (AD 450) as well as ancient Jordanians.

As it turned out, much of the beer in early history was fermented with grain that contained the soil bacteria Streptomyces, and it is the Streptomyces that produces tetracycline upon being fermented. Beer was certainly fermented with other organisms, but the choice of Streptomyces was likely intentional…due not just to alcohol and taste but also to its infection-fighting potential. Some historians believe that this was an early method for preventing gum disease and dental decay as well as other infections, which would account for why children also had tetracycline in their bones. It was their medicine.

Fermented foods have a long history of consumption among early populations, the advantage being that certain organisms tended to produce healthful byproducts as they promoted fermentation. Thus, we have the origin of fermented dairy, soy, and an even wider variety of fermented grain concoctions, not the least of which are the yummy sourdough breads that tend to reduce heart risk. It is this observation that lifts many of our fermented foods into the lofty status of supporting Free Radical Therapy and our Designed2Win model of health!

Managing Eosinophilia

Thursday, September 30th, 2010

How Delivering Free Radical Therapy According to the Designed2Win Health Model Provided a Positive Outcome

Every now and then a FRT health provider may run into a client who presents a confusing situation that hadn’t been solved with meds, and really can’t get solved through FRT without returning to its health model basis. An example is a recent client who demonstrated an eosinophilic white blood count of more than 20%. Less than 4% is normal, so 20% is not healthy, especially when allowed to remain that high, as the amount of toxins released by eosinophils aimed at killing parasites but which can be stimulated by any allergen are certain to damage healthy tissues. Such a scenario affecting the lungs can cause severe compromise in lung function, leading to COPD, asthma or a tumor.

In this scenario the culprit is generally some allergen that has stimulated both the mast cells and the basophilic white blood cells to release histamine. The histamine helps stimulate bone marrow to produce more eosinophils, and the cycle continues until something is done to either blunt the effect of histamine or blunt the flood of histamine-like molecules that anti-histamine meds generally fail to touch. So, what do you do?

Addressing the role of acid stress is always the place to begin, since acidity is certain to amplify the release of histamine due to the mast cell and basophilic response to the allergen. Acidity follows the presence and action of any toxin, including that of a parasite. Thus a more alkaline environment tends to require fewer histamine-like particles. The eosinophil count falls accordingly.

How else you might go about reducing the amount of histamine – and thereby the eosinophil count – can be deduced by reviewing the key source of histamine. It is made from the amino acid histidine. Knowing this you might be tempted to restrict foods that are rich sources of histidine. The problem with this strategy is that histidine also provides the imidazole ring that is so important in buffering the acids all over the body. So, any restriction of the key amino acid can be self-defeating.

The Designed2Win attitude is needed to solve this problem. During exercise, the body releases the amino acid alanine, which serves to stimulate the making of HDL cholesterol while also serving as the substrate for the synthesis of carnosine. Carnosine is used to sponge away the lactic acid produced during exercise, thereby slowing fatigue. Too, the more alanine present at any given moment, the more the body will be prompted to use histidine for the making of carnosine at the expense of making histamine.

Based on this reality, the following suggestion was made to the health provider who was caring for the person in question: Follow the acid/base balancing maneuver with one that diverts histidine away from the making of histamine and towards the making of carnosine. By administering 3 grams L-alanine (not beta alanine) twice daily for a week (for a 150 lb person), followed by once daily for two weeks, the clinician noted a drop in the total eosinophil count from 20% to 6% within 3 weeks. This became far more manageable and less threatening to the person’s health.

Now, of course, you wouldn’t recommend this protocol to everyone you see. Histidine has a life beyond the making of either carnosine or histamine. So easing up on the high supplementation at some point will be essential in order to comply with the body’s winning design.

Alzheimer’s Risk and the APOE gene…there IS something you can do.

Saturday, April 5th, 2008

The thinking of doctors, researchers, and patients alike is so tightly wired to the disease model concept of health that they can’t see the true value of genetic testing. They are mired in the belief that the outcome should always be a new drug tailored to fit the needs of your genetic makeup. Ho hum. Such thinking is at times a real bore.

For the latest “poor us, nothing can be done” attitude I refer you to the February 22, 2008 issue of Science (319), where they announce the forthcoming availability of APOE genetic testing. The reality, is that KNOWING YOUR APO E genotype can result in a better outcome than depression and anxiety. It gives you an appropriate strategy for altering your diet and lifestyle to reduce your risk, while providing great benefit towards better health.

A few years ago I contributed a chapter in a book on Egg Nutrition, edited by Ron Watson, Ph.D., and published by Iowa State University Press. The chapter title was something like “Whole Eggs: The Magic Bullet”. A second version was published in our own Health Realities Journal. In both of those instances references were given of foods that could upregulate or downregulate the expression of this gene.

Depending upon your phenotype, the four key purposes of Apo E are:

(1) To redistribute cholesterol in the body from areas of high concentration to where it is most needed;

(2) to provide a means of transporting mercury and other heavy metals out of the body (via. cysteine residues);

(3) to provide the arginine residue necessary for the synthesis of nitric oxide (NO) to bring about control of smooth muscle and to kill bacteria; and

(4) to repair nerve myelin.

Eggs and butter are known to be most effective in upregulating the gene, while no eggs and butter may be the best way to downregulate its expression. People with Apo E 4/4 should certainly be given this information. Dr. Robert Mahley of the Gladstone Foundation in San Francisco was first to report this, references for which are in the publications mentioned. So, while it is the person with the Apo E 4/4 who must be most careful about avoiding eggs and butter, most people benefit from eggs and butter. These people who express Apo E 2/3, and Apo E 2/2, can not only eat eggs and butter as often as they’d like, but could also expect to control the onset and progression of arterial disease by doing so (as long as they have followed the standard rules for eating eggs). For people who have the Apo E 2/2 reading they should know that the excess arginine leaves them at higher risk for Type II diabetes and the metabolic syndrome, which should give them incentives to really work on this. For people who find they have the Apo E 4/4, Apo E 4/3, or Apl E 4/2 phenotype they are likely to benefit greatly from following FRT and improving glutathione status in the process.

Remember, free radicals that lead to Alzheimer’s are most likely to occur when you are acid. Addressing this is most important for the person with Apo E 4/4, as they will have an abundance of the nitric oxide-producing arginine. So when a bump occurs on the head and inflammation results in the making of excess nitric oxide in the brain you can see how the excess acid from this event could result in the enormous amount of free radicals from mercury (for instance) in causing the initial damage. OK, so you can keep on listening to the poor souls who cannot see beyond the disease model, who are afraid that the testing will cause people to go commit suicide or develop deep depression, or you can get with it and realize that THE HUMAN BODY IS DESIGNED TO WIN, NOT TO LOSE. Knowing allows you to develop a winning strategy. Incidentally, my forthcoming book on FRT will carry that very title, Designed To Win.